A 12 gauge 3.5” magnum 18 pellet 00 buckshot load makes a convincing argument.
You're in 458 WM recoil territory. I'm sure it will make an impression on whatever you hit, but I'll stick with a 2 3/4" load. Even that is in 300 WM recoil territory.
I keep handguns, shotguns, and an AR carbine ready. They fill different roles. I don't like a shotgun indoors. Inside my home the ranges are too close and a shotgun offers me no advantage over the carbine. I actually prefer a handgun indoors so I can have one hand free.
The shotgun is for when we take it outside. Shotguns and buckshot have limited ranges but would be effective from anywhere in or near my home to the property line in any direction. If I ever need to go farther than that I have AR's. And the AR could fill all 3 roles (indoors, close range outdoors, or long range) better than a handgun or shotgun could do all 3.