What do you consider good performance? From the testing I've seen 10-12% doesn't seem very bad. What powders do better for you in this application?
With a low velocity round like 45 Colt, I'd expect plus/minus 5% for the most part but it could be higher.
The position sensitivity of Unique in 45 Colt ammunition is quite noticeable when shooting it over a chronograph. In my testing, powder against the primer averages 10%-12% higher velocities than the averages for powder against the bullet. So, if your averages range plus/minus 5%, you could have a 20% or more difference between the low velocity of powder against the bullet and the high velocity of powder against primer.
If you do not consider the position sensitivity of Unique in the 45 Colt when shooting over a chronograph, the extreme spreads can get large.
Fortunately, due to the limitations of the shooter (me), the rainbow trajectory of 45 Colt and a nominal average powder distribution in the case under normal shooting conditions, the velocity differences really do not show up on the target.
I have been dabbling with Accurate #5 in the 45 Colt. It seems to be less position sensitive than Unique in the 45 Colt. But, I've been working down my inventory of 255 grain SWC 45 Colt loads and transitions to 200 grain WC loads so, I have not worried much about powders as of late. Also, lots of other irons in the fire, who said you'd have lots of free time once retired.
I'm sure there are lots of other suitable alternatives to Unique and AA#5 out there, these are the ones I keep in inventory for this type of application.
Unique works fine which is why I still use it even with all it's "faults".