I can understand the cost vs case fill debate... save a few cents or have a better safety margin against a double charge....
Out of curiosity I ran some numbers to determine how much you would save using Titegroup vs 2400 vs H110.
I used max data loads from the powder manufactures websites for this comparison (ALWAYS start low and work up carefully) and prices from Midway (not including tax, shipping, or hazmat). You can get supplies cheaper elsewhere obviously, and sale prices would throw these numbers out the window. Load data was for a 158gr Hornady xtp on Hodgdons website, and a 158gr gold dot on Alliants website.
Cost of powder per loaded round using Titegroup is about .015 cents, .05 for 2400, and .064 using H110.
This works out to about $1.75 more per box of fifty using 2400, or about $2.50 more per box of fifty using H110.
So the savings can be significant over the long run, but I personally would choose a higher margin of safety.
I personally use W231 in my 38spcl and 357mag loads as well as H110 in 357mag. For comparison using 231 at max charge in the 357mag would be about .02 cents per round (I got my last purchase of W231 for $20 per pound), or .25 cents per box of fifty compared to using Titegroup. Current pricing on Midway would have you at .028 cents per round, or about .65 cents more per box of fifty.
Again, always start low and work your loads up carefully.
chris