Well...
Last deer season I shot a doe a little further back than I intended to... She approached me from my left and presented me with an almost perfect broadside, slightly quartering to me. Problem was, she was moving from left to right across my shooting lane at a leisurely pace. I whistled and managed to make her stop, but I let her stand too long. Just as I was pulling the trigger, she turned her head and started moving again, so my shot landed about 6 inches back in her gut. She didn't stagger or lurch at first, so I thought I had missed- I rechambered and the second round went through the bottom of her heart and messed up her lungs pretty well. She stumbled a few yards and dropped.
I was using my Mosin with 203 grain soft points, and the two bullets did a fair number on her. My first shot, unfortunately, made one heck of a mess, and field dressing her was more of a chore than usual. The exit wound was large enough that some organs had slipped out- I almost didn't have to cut her open...
I console myself with the fact that the second shot ended things fairly quickly, and that she probably didn't suffer due to the extreme shock.
The next day I made up for it with a one-shot on a nice 8-pointer that destroyed both lungs, with that deer expiring in virtually the same spot as the doe. No tracking required.
The other two deer I have shot were both clean, one-shot kills. I have missed one or two others, but my 'ratio' is still good seeing as I haven't been hunting terribly long.