I also have the luxury of a range in the back yard to test- a great advantage. As I've posted elsewhere, 1) I reload alone, 2) no TV, music, or other distractions of that sort (and I love music), 3) no alcoholic beverages before or during reloading (although I like a wee dram), and 4) my full attention on the reloading activity I'm doing.
Many of the usual precautions have been mentioned. Although I load for all three types of ammo, only one type of powder or primers is allowed out of the storage locker at a time. If I'm using a load I've done before (and I've reloaded for 50 years, some of those loads go back a ways), I pull the card on it, and double-check for the correct components. I never, EVER, trust to memory.
I've graduated to an electronic scale, but it's always plugged in, warmed up according to directions, and calibrated. It's always on while I'm reloading, used to periodically check for the correct weight of powder being dropped.
Last, and it wasn't mentioned specifically, if you experience a squib (I have!), STOP. Immediately unload the gun and check for obstructions in the chamber / cylinder / barrel. The squib that kills puts a bulled just far enough up the barrel to chamber the next round, which then destroys the gun and who knows what else.
I had a "lucky" squib experience a while back, using some ammo of unknown provenance I should have known better than to shoot. A revolver squibbed where the primer put the bullet into the forcing cone, but not enough to clear the cylinder. This locks up the gun so it's obvious something is very wrong. I keep a friend's 1911 barrel above my reloading bench to remind me of an "unlucky" squib. The thing is ballooned out just in front of the chamber, luckily the barrel didn't burst.
And, as a corollary to what some people have already mentioned, if you have had a squib, there's always the possibility of a double charge lurking in the rest of that batch.
This is a wonderful pastime, but when doing it, unlike some other pursuits, it demands our undivided attention, and our heads in the game.