I usually don't leave the house without a little .380 in my pocket. Small, flat, and I never leave home without it. Too handy not to.
That said, I usually try carrying my beloved larger semi autos and eventually switch back to my trusty SP101 2.25". It's small enough to conceal, hangs on my belt with an inspiring heft, and I probably couldn't wear it out were I to live 5 lifetimes.
I love my semis. However, I just naturally gravitate toward snub nose .357s.