I shoot four different 45 Colts, with barrel lengths up to 7 1/2 inches, I use 7 1/2 grains of Unique behind anything from 185gr to 225gr with good results. Moving up to 8.0 or 8.5 grains improves nothing but recoil. Mostly lead but maybe 5% jacketed; leading minimal. One Ruger, 3 S&W.