The nylon bristle brushes are a good way to get the solvent into the bore for a good soaking. You can brush it out and leave it sitting for awhile or continue on. After that, I take a stainless steel .45-caliber bristle brush and push it through. Make sure you don't reverse direction until it pops out the other end of the barrel. Then run the patches through. Don't feel like you have to get all the fouling out, just go for a shiny barrel.
I use oversize brushes because they clean better and last longer. Some people buy diesel fuel and throw their guns in that overnight. It can be filtered and used again.
The only place where you have to be careful is the area around the muzzle. It's a good idea to have a guide that fits in the recess and keeps the rod from damaging it. These guides come with a lot of cleaning rods. And about the cleaning rods, I'd also use stainless steel or brass rather than aluminum.
For lubrication afterwards, be careful. Just a drop under the ratchet should do. Never more than a drop anywhere. Use a good lube like BreakFree; don't use machine oil except one drop to the action (cock the gun and squeeze one drop between the hammer and the frame. Machine oil is fine for this as it doesn't leave residue. If you use BreakFree or some other teflon based lube, you can get a buildup in the action, and that you don't want.
Congrats on the Ruger. It's a very good choice.