Rifle, yes. Contender pistol, yes. Revolver, probably not. 357 really builds speed in longer barrels so it still has the momentum at the point of impact to drive deep, expand, and do a reliable job at killing the critter. Revolvers in the 6” variety will be much slower and may still do the job but not nearly as reliably. I am assuming that the shooter is good enough to make a hit, but that is more difficult most of the time with a more traditional handgun. Having shot deer with a .357 in 4, 6, 10, and 16 inch varieties, at extended range I would absolutely not trust the 6” to 100 yards.