When you’re using genuine black powder OR Pyrodex (a black powder substitute) the exact amount (by weight) of powder is not nearly as important as making sure there’s no dead air space between your powder charge and the base of your bullet – or between the wad (if used) and the base of your bullet. You can’t put too much black powder in a cartridge case, but you can sure put too little, and if you leave dead air space in your cartridge case after seating the bullet, you could end up with a ringed chamber.
I could cite numerous sources for the above information, but a real good source is “SPG Lubricants BP Cartridge Reloading Primer” by Mike Venturino and Steve Garbe. Another
pretty good source is “Loading the Black Powder Rifle Cartridge” by Paul A. Matthews.
My own black powder cartridge rifle is a .45-110 (2 7/8” case) Shiloh Sharps. Through experimentation, I’ve found that putting 73.3 grains (by weight) of Pyrodex RS powder in the case, then seating a Montana Bullet Company 500gr. RN bullet and a .30” thick vegetable fiber wad, compresses the powder about 5/16”, and that’s about right.
BTW, also through experimentation, I’ve found that a .45-110 Sharps case filled clear to the top actually only holds about 106 grains (by weight) of genuine black
cartridge rifle powder. And that’s after compressing the powder charge slightly by dropping it through a 24” long drop tube. My favorite .45-110 Sharps load is about 95 grains of slightly compressed black
cartridge rifle powder behind a 500 grain RN bullet and .30" vegetable fiber wad.
I haven't used my .45-110 for big game hunting yet, but I have shot at a few rockchucks with it. Never hit one of them (I'm not Quigley) but those rockchucks must think they're under an artillery barrage when those big ol' 500 grain bullets land nearby.