I think that as long as the reticle isnt too think 4x is plenty for anything inside of 300. I could see an issue if it were one of the heavy duplex, or a post. Most of my variables are 3-9s or higher, but they are almost always left on their lowest setting. Some times i remember to turn them up before firing, but very often not.
Ive got three 5x or below scopes, and the only one id have an issue with a shot at or over 200 yds is my Brunton Eterna, and thats because of the dot.
Why it has a dot i dont know, wouldnt have bough it if id realized it wasnt standard duplex....it is a very nice scope tho, if a bit critical on eye relief.
Gotta remember most of my targets are axis deer, or feral goats and sheep, they usually top out at 100-120lbs and have relatively small target areas. The flip side is we dont have seasons, so I have a great deal of time spent poking holes in them over the years, might just be a familiarity thing.