The Neos is a good entry level .22 LR pistol. It does not have a lot of aftermarket parts and accessories like the Ruger Mark I,II, III pistols, but it's a more user friendly than the Ruger. The accuracy is good for an entry level .22 LR pistol. If Beretta ever releases the long promised carbine kit, the gun will become more popular.
As far as drawbacks go... The gun's safety is positioned in an awkward place, but the pistol will probably not be used outside of plinking purposes so it's not a major deal. Some find the Neos' trigger a little on the heavy side but if you get one and don't like it, the guys over at
www.rimfirecentral.com have worked out a trigger job that does the trick. If you're used to regular duty guns, you won't think twice about the trigger. Also, try to handle one at a gun shop or gun show so you can see if the grip width and angle works for your hand. -It would be better if you could try one at a range before buying it, but I'm guessing if you had the range option you would've tried it out instead of posting your question...
In regards to jamming, as a class, .22 caliber pistols are notorious for being finicky with cycling different ammo. You can find many threads asking why whatever .22 won't cycle X or Y brand of ammo. I have several friends with the Neos and so far no one has encountered ammo sensitivity with their particular choices. I know CCI's Mini-Mags generally work well in almost any .22 LR, so if you get something, you might want to run those through the gun.
Good luck.
pair of small dark 
sunglasses before you buy it...misteeerrrr
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