In general, faster powders are more efficient in short barrels, ie. Bullseye, Red Dot, AA #2, #5, W-231. You don't want something that's going to put a big fireball out the muzzle. However, you're typically not going to be able to completely avoid that in a snubby.
If you're looking for performance in a snubby as defensive carry, bullet choice is more important than powder since you're not going to make the most of the magnum cartridge, regardless of powder. Look for something that either opens dramatically and quickly at lower velocities or something that has good penetration like a jacketed softpoint.. XTP will open up somewhat, but proably better in a little heavier bullet that has the momentum to fully open up. Speer/CCI Short Barrel Gold Dot is another good (better) choice to dramatically open the HP, though I'm unsure whether or not they make in .357 . . . probably do. Then, too, I would recommend a heavier weight.
Of course you are going to use what you want, but as many folks have posted in this forum, it might be the best idea to use factory ammunition for self defense . . . one less thing for a personal lawyer to use to get money out of you if something goes bad. Lead SWCs with a quick burning powder will give you more practice loads for the same price as the XTP and lead's easier to clean from barrels than copper.
Went overboard, didn't I? Just another poster's opinion to file away where you wish.