PLEASE be sure to LOCK the thing somehow. Glove box, car safe, something. Your "security through obscurity" (backpack, KFC, etc) solutions scare me. (I prefer physical security WITH obscurity too!)
I have a "Secure-It Handgun Storage Safe:"
http://www.amazon.com/Secure-It-Secure-It®-Handgun-Storage-Safe/dp/B000HBB15U/
I secure the cable that comes with this around one of the front seat bolts. The box itself hides under my driver's floor mat. Easy, discrete access (pretend to be tying your shoes), but somewhat secure.
Its this a perfect solution? No. Anyone with a pair of bolt cutters could cut the cable easily. However, it should be enough to stop an amateur "smash and grab" type of car break-in. It will also keep the gun safe from pilfering fingers of any children or inexperienced friends.
ALSO, this has the advantage of being easily removable for carrying into a hotel room or sticking in your briefcase to take with you, and still being "secure" from folks playing with it.
I'm open to suggestions if anyone has a better solution, btw.