You need to have a system to do it comfortably. A combination of proper pant size, sturdy belt, proper holster. Most important being the holster. I've got no less than 25 different holsters , all in search of the perfect one. Don't believe the nonsense from online holster sellers, they all claim they feel great and what works best for one person may be impossible for someone else. No single holster does it all and holsters designed for multiple positions will me mediocre at best in all positions and total garbage most of the time.
So it's an impossible question to answer. I'll show you my absolute best, most concealable and comfortable holster to give you an idea of what works for me.
That's a black rhino holster and it's kydex. I can't use leather anymore after using kydex, leather is miserable for me and I find it hot, grabby , noisey and flimsy. But some guys love it.
The holster you select must be made for your exact gun, that's very important .
Next is belt.
Get one you can't fold in half width wise. That's important if you can grab it between your thumb and index & middle finger and fold it, it's no good. I've gone down the leather/bullhide belt route and plain and simple they collapse if not internally reinforced. Plus if you're bound by having specific holes for sizing it isn't ever going to be just right. I prefer a nylon belt with reinforcement , the one I've been using for the past few years is a 5.11
https://www.511tactical.com/operator-belt-1-34-wide.html
You can cinch it up a little or loosen it a little if need be. Wider will be better.
Pants, just go up a size or 2 so you're not straining to button them. I wear a 34 waist so I buy 36 pants. Not much more to explain.
Many folks will say how great appendix carry is . For me it is not. I have a few holsters of that design and only use them if I'll be walking or on my feet a lot and concealment is essential and I'm lightly dressed. I've heard people say that it's great if you don't have a gut ect. Well, im 6'1" , 185# and have zero gut, it's awful for me. But that's me. This method conceals the best and keeps access to your gun right there but it's impossible for me to sit comfortably with a gun in front.
4:00 position is very comfortable but will be exposed when you bend or reach. It's common for me to wear a button down shirt open in the front and obviously untucked to hide my gun better.
The last thing I can think if is to consider the grip length of your carry gun. That's the only thing that will show. For me a 2 finger grip is fine. I train like that and shoot like that regardless of grip length. The barrel can be 10" long and it'll conceal fin but if the grip is long it's likely to poke out.
Goodluck and let us know how it's going for you