Bought the 22/45 for the wife to take a Basic Pistol course with. She likes my 1911 with the .22 conversion on it but has a hard time minipulating the controls. Plus the tight hammer spring on the 1911 makes racking the slide hard for her unless she cocks it first...not a good situation in a classroom setting. I was unsure of the polymer/nylon frame until I thought about all the centerfire pistols with them. The ruger 22/45 is actually a nice set up, more like a composit AR. Grip frame is 'plastic' and the whole upper is steel, no steel sliding on plastic or on steel 'inserts'. She likes the lighter weight of the 22/45 over the MKIII. Pick a few up and see what feels good, you can't go wrong with a Ruger .22