Scatterguns notwithstanding, reaching around a doorway and populating a room with handgun fire could be a very safe way to do that kind of ugly business.
I can't imagine shooting blindly around corners with a handgun is terribly effective. A soldier has grenades for clearing a room.
The handgun is trying to be justified as a short range weapon, but why would you switch from a carbine with significantly superior firepower when you are involved in close combat. A rifle isn't any harder to hit with at close range than a pistol, since many people seem to forget it can be pointed in a manner similar to a shotgun.
I didn't state it clearly enough, but my main gist is that one of the reasons the .45 is so revered is that it just isn't used that often. If a .45 became the standard issue pistol we would begin seeing reports on how there were opponents that didn't drop dead from a "solid" hit. If the military and the police departments moved to .45 we would probably begin hearing similar sentiments as we hear now towards the 9mm, although a little tweaked, like "Man, I wish I still had that Glock 17 with the seventeen round magazine! I had to run my G21 dry trying to stop those two guys! Imagine if there had been another!"
People love to haul out the old Moro anecdote where SAAs were brought in to the Philipines because there were guys taking multiple hits of .38." What so often gets neglected is that the Moros were taking multiple hits of .38 Long, which is a cartride that gives only 195 ft-lbs of force at the muzzle. The 9mm Parabellum, on the other hand, runs above 350 ft-lbs, which coincidentally about what the .45 ACP runs.
Perhaps the greatest endorsement of the 9mm is the number of countries that issue it. If it was so ineffective why does it see such widespread use? Even Russia is now issuing their own hot version of the 9x19.
Basically what I am trying to say is that if you drop the 9mm for the .45 you will find that there will be just as many complaints, as pistols are just not that powerful. And in combat they are a last ditch weapon, despite how much people glamourize them.