I have a P22 and like it alot, I bought it with the intention of my fiance using it, but I find myself putting at least a hundred or more through it every trip to the range.
Our P22 has eaten everything it's been fed, occasionally it jams the first round when a new person loads the mags as they don't get it all the way in. Aside from that it's cycled Mini-mag, Federal Bulk, Remington Golden bullets, and Winchester Super-X without incident.
At first the ejection was erractic, but I got a new extractor for a local guy and there's tutorials online to fix the stock one. I should note, it functioned fine with the old extraction, just had a tendancy to bean you in the head once or twice a mag. Now it's all back and to the right.
Mine hasn't shown any significant wear, and there's plenty of guys on another forum that have tens of thousands of rounds through theirs without significant wear. I'm sure someone will post the picture of the P22 with the broken slide about now.... My feeling is that there's lemons in every batch, it doesn't seem to be the majority or even close, but it has happened.
With all the being said, if you're going for bulleyes type stuff, the Ruger is a better choice. The P22 is a lot of fun as a plinker and just going through the ammo at the range, but it's not super accurate.
Another option if you have a little extra money, would be to buy a cheaper 1911 that you like and get a .22LR conversion for it. Several companies sell them, and that way you could practice on the exact gun you'll use in the larger caliber.