As
earplug said, if you can find a combination of spacers for each cartridge that eliminates the need to adjust the drop die/powder measure relationship, that makes life easier. Adjusting the drop die up or down on the press to to get the powder measure to cycle full stroke is easy.
I bought a Hornady L-N-L progressive press first and did all my development on the Hornady. But everything I did on the Hornady, works on the Pro2000. The RCBS Pro2000 and the L-N-L use essentially the same case activated powder drop system, the L-N-L is a license built version of the RCBS one. I prefer the Hornady L-N-L case activated powder drop die over the RCBS and use it on my Pro2000. There are a couple little differences on the L-N-L case activated drop die that I like but I could live without the changes.
When I finally bought a progressive press, I was loading something more than 10 different cartridges. To make the powder measure changes between the different cartridges, I made custom drop tubes with the idea that no other adjustment of the drop die would be necessary. I got close to the goal but I still needed to tweak the drop die to press adjustment so that the powder measure cycles full stroke. It is not difficult as I use a non-locking jam nut on the drop die so it is easy to loosen the nut, make the adjustment and re-lock the jam nut.
As you increase the number of cartridges you load, you could have a powder drop die and spacers set up and adjusted for each cartridge. Then you should not need a powder measure for each cartridge.
With micrometer adjusters on the powder measures, you can record the setting you use for a particular cartridge and powder charge. Then, when you return to that set-up, it is quick to get the powder measure close, then you can tweak the adjustment to get the powder charge dialed in.
I have an off press powder measure stand that I use to make the beginning adjustments of the powder measure. It is easier to operate the measure by hand. When the powder measure gets close, I install it on the press and finish dialing the powder measure in by operating the press dropping the charge into a case. I use a fired case with the fired primer still in place. I transfer the powder to my scale.
I use a modified Reading 10-X powder measure for most of my handgun powder charging. I reload 204 Ruger and 300 Blackout on my Pro2000 using the Uniflow with the small drum. The same drum would work with 223 Remington as
earplug said.
These are some of the things I do but it is by no means the only way to efficiently cartridge change the powder measure on the Pro2000.
I hope this helps giving you some ideas to pursue.