I love the .357 and a Uberti so chambered is what I typically carry around the house in case I see a coyote or hog. But when I'm hunting with a revolver, it's either a .44 Special or a 45 Colt, both being Uberti's. I've used the 45-270 SAA on a buck and a javelina, but mine was the hollowpoint version at 263 grs. and running around 1040 fps out of the 5 1/2" barrel. It whistled through the little javelina with no signs of having expanded, but definitely expanded on the buck.
I prefer penetration so I won't be using the HP version anymore, having switched back to the solid SWC that weighs 288-290 grs. I've been shooting it in a Uberti Frisco and it has given me some very satisfying accuracy.
I want to say the Unique load is running somewhere around 850 fps, but I don't recall and my load log is in the shop.
^^^^^This is the load I settled on. Pressures are in the 20,000 psi range so it's fine in a New Vaquero or in the recent Uberti 1873 reproductions.^^^^^
That RCBS bullet running 900 fps would be fine on any whitetail, based on my experiences in shooting them with .44 calibers SWC's running around 935 fps.
Again the .357 will definitely work, but I don't trust a HP in a caliber that small to penetrate deep enough on anything but broadside shots, and the SWC's and WFN's don't have near the frontal area of a big ol' .45 caliber bullet.
35W