You really can't go wrong with a .22 Ruger Single Six.
Just to muddy up the waters here, I will point out that Ruger also makes the Bearcat. The SS is approximately Colt Peacemaker size, the Bearcat is about 3/4 size.
Bearcat is also available in stainless, has fixed-sights only, operates on the old Colt "half-cock" system, and runs about $325 NIB in Texas.
I have small hands, and date short women, so I bought a Bearcat instead. Single Six is somewhat better as a target gun (adjustable sights, longer barrel), but if you want a smaller version that you can toss in a jacket pocket, which is also extremely accurate and durable, go for the Bearcat.
Soon as I get home from Christmas break, I'll post pics of my my Bearcat with the new elk-antler grips I just bought for it ($59).
-MV