The bullet in a .22 WMR is slightly larger, so the Ruger will not shoot the .22LR quite as accurately, even with its own cylinder because the barrel is made to accommodate the larger bullet. But...most people won't notice and it's still accurate enough to nail squirrels, rabbits, etc. If you want maximum accuracy, buy
Paco Kelly's Acu'rzr. It gives you the chance, with just a few very light taps, to not only put hollow points in standard ammo, but enlarge the bullets ever so slightly. (Just tell Paco what kind of gun, or guns, you'll be using.) He'll send the right Acu'rzr and your Ruger will spit out bullets the proper diameter.
Do a search for reviews. If you become a member of
Paco's forum, he'll send you his tool/s with FREE SHIPPING.
Again, many people don't see any real accuracy difference, so unless you're competing, I wouldn't worry about it.