My wife had trouble with everything I brought for her to try. Brought her a Keltec PMR-30 and she seems to like it. Lightweight pistol at 15 oz., 4" barrell, 22 magnum caliber, 30 round magazine, reasonably accurate. She can rack it with difficulty, but with a 30 round magazine, it is unlikely she will need to, as I would expect the fight to be over with by the time she has shot 30 times. She has no trouble aiming it, taking the safety off, or pulling the trigger. Not the best caliber, but better than .22lr and .25 acp. Just a thought.