My Pop hunted elk with a .243 for several years, 2 bulls and 3 cows were taken with it. One bull took 3 shots to put him down, all behind the front shoulder @ 100 yds. The others were neck shots at less than 100 yds, how much more humanely can that be? I know this will probably cause a ruckus, however... My grandpa had a .250 Savage for about 40 some years, he killed elk, deer and black bear with it all of that time, using 87 and 100 grain bullets, that was all the weights they made then. Like someone mentioned about moose not knowing they're dead after a good shot, dead is dead, no matter the cartridge, when they go hooves up, they're done!