Custom dials fail in many of the same ways as any drop compensating reticle. The knob is marked to correspond with one ballistic solution - one bullet velocity and ballistic coefficient, in one environmental condition. If you never hunt anywhere other than your home field, only in similar environmental conditions (pretty difficult to control this one), and never expect to really be dialed perfectly, then they can be usable. A few years ago, I called coyotes in 3 states over a 2wk period where I varied elevation by 6000ft and temperature by 50 degrees.
I called at home in Kansas, then Arizona at the same elevation as home, but higher temp, Colorado at the same temp as home, but higher elevation. My zero didn’t shift at all, but the combination of the temperature sensitivity of my powder and the change in environmental conditions meant I had 4-6” difference in drop at 600yrds. I had a range card at the time for use at home, but it was wrong in both Arizona and Colorado... I had to make a new version for those hunts. Pretty easy to write numbers on a piece of paper while I was flying between locations, but it’s a little different story to order new dials just to correct for a couple 5 day hunting trips.
Naturally, you can count clicks away from the standard numbers on your custom dial to correct for environmentals, but if that’s the game, why bother with the custom dials at all? Is it actually different to dial an extra click above 2.2mils, instead of an extra click above 500yrds? What if the coyote in my scope isn’t at 500, but is really at 543yrds? I have to know how many clicks to dial past 500, oh yeah, and then know how many clicks up or down from there to correct for environmentals... There are no free lunches - gotta know enough about your real trajectory to make your estimate based on the actual range in the field, under the real environmental conditions of the shot.
Free is free, in the case of the CDS dials offered for many Leupold scopes. But a waste of time is a waste of time, and money spent for nothing still gets you nothing.