Right this second, I have two 22-250s, a 223, a 22 K Hornet,, and a 224 Valkyrie. One of the 22-250s is a heavy varmint rifle and I use it on prairie dogs. The other rifle is a light sporter that I just don't use for much. I have thought about taking it deer hunting, but haven't gotten around to it because I have better deer guns. I might take it after Javelina this coming season. It would shine on that.
The 223 is a nice little cartridge, but I don't shoot it much. Just punch paper every once in awhile. I got the rifle as a gift, but it can't match a 22-250 and it isn't as economical or as quiet as a 22 Hornet.
I really like the 22 K Hornet. Extremely quiet. I often shoot it without hearing protection. It is also extremely stingy with powder. I get 600 rounds or more per pound. That is especially helpful in time of shortage. Works well on Pdogs and it works well on coyotes as long as you keep the range down. I generally don't shoot anything further away than 125 yards. I did take a coyote at 110, but I would prefer them much closer.
I got the 224 Valkyrie in a long range rifle not very long before the virus came over, so I don't really know what I think about it just yet. I've played a little and it shoots okay, but components will have to return to the shelves before I really work with it and form an opinion. The cartridge might make a pretty good deer round with 80 to 90 grain bullets although it isn't as fast as a 243 with those same weights.