I'm going to catch flack for this, but this is where a loaded magazine and an empty chamber is my preference. I often carry a handgun in my glovebox or console. I've tried doing it with a loaded chamber, inside a holster, then inside the glovebox. It still takes 2 hands and some time to get the gun out of the holster when carried this way. I find it faster and easier to just chamber a round in this setting.
For quite a few years I carried a G29 in 10mm as my hiking/camping pistol. When worn on my hip I kept a round chambered but was never comfortable with a loaded chambered Glock in my sleeping bag as I slept. I kept an empty chamber at that time. When S&W came out with their M&P Compact in 10mm with a 1911 style safety I bought the 1st one I saw. It's only marginally larger than the Glock, but with a manual safety I will sleep with a loaded chamber.
Even the manual safety on a semi can become disengaged sliding around in a purse or glovebox. My wife carries in a small leather purse that she can carry over her shoulder or wear as a belt pack. There is a pocket just big enough for her Sig 365 to fit. IMO that serves exactly the same role as a holster and she carries with a loaded chamber, safety on.
1st off - Glocks or striker fired pistols that don't have a manual thumb safety absolutely require a rigid leather or kydex holster that protects the trigger. That's the 1st rule of carrying a chambered striker fired pistol - it must be in a holster that protects the trigger.
Soft leather or flexible leather holsters - can result in a ND/AD while the pistol is holstered.
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I go back to my carry gun storage solution - all loaded & chambered carry guns are kept loaded / chambered in their holsters at the end of the day.
When you come home you take your holstered, loaded, and chambered pistol off as 1 unit and either store it as such or leave it on your belt / pants. In the morning you put that holstered loaded / chambered pistol back on your belt or into your pocket. The only time you should be unloading your carry pistols is when going to the range or when cleaning it.
Camping, staying in a hotel, etc your chambered / holstered pistol goes in your sleeping bag or under the pillow with you.
In your vehicle - loaded holstered pistol goes in glove box or center console. However, I prefer to keep the pistol on me at all times, while driving.
I prefer a Kydex holster that clicks or "locks" on to the pistol and protects the trigger. A tight fitting rigid leather holster is good to go as well. Depending on the style of the holster, you may need two hands to get your pistol out of the holster, when the holstered pistol is not on your body.
I carry my pocket 9mm handguns in an Alabama Front Pocket Holster.
It has a corner of the holster folded out that allows you to push the holster off 1 handed.
So for women and purse carry / off body carry, they need to either have a holster mounted in their purse that retains the pistol or use a kydex holster that "locks" onto the pistol. They should be able to un-holster the pistol one handed but not have the pistol come loose of the holster on it's own. A proper RIGID holster would've prevented this tragedy.
jmr40 - I would recommend your wife use a kydex pocket holster or kydex trigger holster mounted to the inside of her purse. The problem with a pistol like a P365 or Glock that doesn't have a thumb safety is that the trigger could be pulled through a soft sided leather or cloth purse.
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The trigger holster could also be your 1 handed draw solution for a glove box or console box stored pistol. Tie or bolt the end to something.