I meant no offense to .40 cal lovers when I said I didn't see an iconic design in that caliber. It's just my own personal preferences. A S&W 4006, to me, is just a 5906 with a slightly larger bore. My 3rd Gen is a 9mm, I'm happy with it. I'm also happy with my other 9mm's.
In just my own humble opinion, this is the issue- 9mm and .40 s&w have a large overlap; .40 gives you a little more oomph, and 9mm gives you a couple more rds. The guns chambered in either have versions in the other. Again, in just my own take, there is no one gun that makes me say "oh, I have to have one, and it must be in .40", not for adding something to the collection. Sig P22x, Beretta 9x, Hi Power, CZ 75, 3rd Gen S&W... both in 9 and .40. I chose the 9. This makes my ammo purchases easier, because I have other 9's, and keeps me from having to buy different calibers, and carry different to the range.
Now, in contrast, I have a 1911, and that to me says .45 acp. I only own one 1911, and it's my only 45. That is my example of getting the gun as it was intended to be, or "iconic".
To be fair, I started out with 9 and built on that. If I were starting out now, the price of used .40s might sway me to go with .40 instead of 9. I don't think you could go wrong with either, but MY universal caliber is 9mm.