I keep my .45C loads no hotter than 800-825 fps MV in any of my revolvers chambered for it, and I have three; a 4"S&W M25-5, a 5-1/2" Uberti 1873 Colt SAA, and a 7-1/2" Taylor's (Uberti) Remington 1875, and that's my own chronographed data and not what the manuals list. I know them to be safe loads and they don't beat up the guns. There's no real point in pushing hot loads in these guns. A 250 grain JHP or RNFP will go through a white tail at 50 yards at that velocity and a shoulder shot will knock it off its feet like it had been hit by a car. The same load I make for the revolvers will go just under 1000 fps in my Henry Big Boy with a 20" barrel. I've done some heavier loads for the rifle, up to 1100 fps using the same bullets, but their only advantage is a slightly flatter trajectory for 100 yard shooting.
The Hornady manual splits .45C handloads into three categories in the manual: rifle, "standard" revolvers, and another for Thompson and Ruger handguns. I've founf using the standard loads and working up a little at a time gave me better results for the rifle than using the rifle data. Accurate #5 works great for the handgun loads, Accurate #9 is good for the rifle (slightly slower powder). Power Pistol works well for both.