I'm assuming that these are going through a pistol? If so, as others have said, if you can tell the difference, then you should really be shooting for some firearm company. I know I can't shoot well enough to see the difference in the +/- .2 gr variance in powder and the +/- 1 grain in my Rainier plated 230gr bullets and the variance in OAL.
If this was going to be rifle rounds through a rifle bolted to a solid foundation and shot for accuracy testing then I could see how a few grains in bullet weight could make a significant difference in accuracy.