Well, it beats unarmed by leaps and bounds ... but not really a great choice given the inexpensive HD-appropriate guns on the market.
It is an interesting gun, and if reliable would be about the best rimfire pistol for HD (although the KelTec offering on the way to market beats it handily in capacity with 30x in a flush-fit mag) ... but seriously, why hamper your ability to repel an invasion, inexpensive shotguns, handguns, and carbines are easy to find, if recoil and budget are issues there are pistol-caliber carbines (KelTec and Hi Point come to mind with ugly but serviceable offerings) and everyone needs a carry handgun which can be the HD gun as well, since it should be the most practiced-with gun in the house.
So ... how concerned are you about home invasions? Had some in the area? Economy on a downslide with people getting broke/stupid/desperate? Just wanting HD on principle?
Because if you have a serious concern, that pistol is incredibly inadequate compared to other options ... but if you're just arming up on principle the axiom of "beware the man with only one gun, he probably knows how to use it" comes to mind, and assuming reliability and serious training .22mag is so much better than nothing that I wouldn't scoff at it (some will).