I have a .22short/Long/LR rifle (Remington Model 41), a .22mag (Henry), a 17hmr (Marlin) and a 17 Hornet (Savage). I don't want to give any of them up, all do certain things wonderfully, all are very nice rifles and I particularly love my old model 41 with the 27" barrel.
I have a farm that gets all kinds of critters coming around. If I want to kill anything larger than a squirrel, I use the 17's. If I want to "hunt" for small game I use the .22lr. I can use the 22mag for both, but it's pretty loud.
If I'm going to kill any varmint, the 17hmr is a good round with good accuracy, and combined with my Marlin rifle and scope, it's extremely nice. The 17 Hornet is just a whole nother world of awsomeness. The Savage I got is their top of the line model with the thumb hole woodstock, I put a nice scope on it, it's like shooting a laser beam, zero recoil., this is the go-to rifle for coyotes, dillos, nasty large varmints (I don't even know what these things are, but they are about as big as a beaver but they look like huge ground hog??).
My Henry 22mag is just a fun rifle to have around, it's a lever action rifle and can be used for varmint killing, hunting and even home defense.
When the .22 craze was upon us, I could not find .22 ammo anywhere, but there always seemed to be some 17hmr ammo around. So, that's another consideration...