I understand the appeal of a shoulder shot to "break down" a dangerous animal. However, when shooting an animal you're going to eat, why would you put a bullet, deliberately, through a roast? Everyone talks about the vitals being behind the shoulder bone. Nobody mentions that they protrude behind the bone into the other half of the animals chest cavity. The rib cage protects these organs. Ribs are much easier to punch through than a scapula.
From the side, put your bullet directly behind the shoulder. This hits lungs and pretty much everything else but the heart.
Quartering away, your entry point is behind the close shoulder and exit point is the off shoulder.
Quartering toward, your entry point is the animals chest (obviously) and the exit point is the portion of the animal farthest away from you, to maximize bullet travel through the chest cavity.
Quartering shots MAY result in a busted up shoulder, but the target is internal organs. In my opinion, deliberately shooting a shoulder, making your bullet pass through muscle mass and bone before reaching ANY vital organs is foolish. Not only is it wasteful of meat, it demands far more of bullet performance than is needed. And we ask why everyone is convinced you need a .999 LoudenBoomer to hunt anymore. Because we've lost sight of how to make the most of what bullet performance we have available to us.
There's no medals for shooting game at extreme ranges. Stalk as close as possible, then get one yard closer. Choose your shots wisely. Be willing to pass on marginal shots. Unless you are a subsistence hunter, this is a hobby and sport. Do not make an animal suffer needlessly because you lack the patience or skill to pull off the shot.
Tracking is a skill we all need, but the best result is an animal falling within eyesight. No trophies for "I tracked him all day and finally found him. Bullet in the ass. One shot, one kill, baby!"
Before you tell me I'm being unrealistic, I've shot a lot of deer. Not hundreds, but dozens. Shotgun slug, .308 and handgun. I have NEVER had to track a deer more than somewhere between 70 to 100 yards. While I am a decent shot, especially with a rifle, the main reason is I choose when to shoot, not the animal. If I feel out of control of the shot scenario, it's time to change the scenario, not get boxed in by circumstances that you can change.