I still find it amazing how much difference one tenth of a grain of powder (that's 1/70000th of a pound) can make in how well a bullet/powder/brass/primer/gun combination performs. I tested a tenth-grain increment ladder today around my best grouping charge weight of 2400 in my .357 Blackhawk with Hornady 158-grain XTPs. While the 13.9 grain group is statistically the same as the 13.8 since both have a max spread of 2.7", I'll take the 13.9-grain group every day of the week, and the 14.0 and 14.1 are obviously not even in the running. Distance is 25 yards, shot from a portable bench with the frame of the gun and my forearms rested.
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In the first ladder I did with 2400 in 0.3 grain increments, the 13.9 grain group did the same thing: five shots in 1.5" and one outlier. It could absolutely be me, but I'm going to load a couple dozen more of that load, and shoot groups keeping track of which shot comes from which chamber, just for grins and curiosity. Since I'm shooting jacketed bullets it seems unlikely that inconsistent throats could make that much difference, but anything is possible.
Still happy with the way this is going. I have a ladder with AA #9 yet to run. I'd like to get settled on a good load so I can really sight the gun in proper and start practicing with it, though. Deer season will be here before we know it.