There's a lot of overlap but not 99.99%. I realize that most people don't take anything more than deer-sized game with a handgun and for those folks, it's probably 100%. However, for those who hunt bigger game, the gap between the two is more obvious. On the top end, the .44Mag is really the bottom of that group of big bore cartridges that really take advantage of their capacity for heavy bullets and slow powders. The .41 tops out with 265/280gr cast bullets and just can't compete with the .44Mag and .45Colt, where 355-360gr bullets really shine.