I have used both powders for my 44 Magnums. But I used way more Unique than Blue Dot for my handguns, but my Puma seemed to like Blue Dot better (or I did). I can't give a definite answer, BD vs U, as I worked up accurate loads for both in my 5, 44 Magnums (mostly 240-265 gr. cast bullets). Light loads of Unique seemed more consistent in accuracy than Blue Dot and I used Unique a lot for my other 4 handgun cartridges...