.460 Roland runs 40000 PSI. .45 Super runs 28000. .45 Long Colt is an equivalent diameter black powder era cartridge with maximum pressure of 14000 PSI.
Even if you can find a .45 ACP conversion cylinder to chamber them, the pressure will probably be beyond the limits of the frame.
TL,DR: bad idea, unless you want to be known as 'Lefty'.