Fantastic discussion on big bores and I define big bores as anything equal to or larger than a 41 magnum from a handgun. No, 357 mag is not a big bore to me.
There have been so many useful comments in this thread that I think it out to be re-titled so that people can find it more easily.
To start off, I also think the 45-70 from a BFR is a bit silly regardless of the cost of ammunition. That doesn't mean it would not be an effective hunting round or just plain fun to shoot (some
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Sighted dead on at 100yds, you're 2" high at 50yds and 4" low at 125yds.
That's just about perfect and easily handled even without the aid of optics. Hmm... optics..... You know, I don't know about you all, but shooting a handgun at 125 yds with iron sights is just sort of like aiming a regular barreled and sighted shotgun (bead) at 50 yds. It lacks precision to me. But one might feel they are getting precision from their scoped or red dot/laser device, but the reality is different. What the sights do is make aiming easier and helps to build a little confidence for the shooter.
However, in practical terms, if you can hit a 6" paper plate at 100 yds with a handgun with some regularity, it is plenty of precision for larger game hunting and the 2" high and 4" low works well with that perspective.
Choosing a big bore? I have not shot X-frames beyond a few shots at the range where someone let me shoot their's and I let them shoot mine. Love the concept of the 500 S&W as it is still a "handgun" and not a hand rifle. Choosing should be based on your experience and objectives. My objective with a handgun for deer hunting is the ability to break bones such as with a shoulder shot. That's why I tend to not want a 357 mag for deer hunting. However my experience is lacking with the 357 mag as I went quickly to 41 mag for hunting and pretty much didn't shoot 357's for years after that. Plus I like the 41 mag a lot better and so it's a case of why bother?
Added: I suspect solids from a 357 would break bones.
As many here know, I am a 41 mag guy and bumped up to 480 Ruger a number of years ago for deer hunting (or whatever big game hunting I might do). Like it and it's plenty of everything... practical power, manageable recoil, accuracy and so forth and all the things I look for in a big game revolver. That said, the platform matters and I have found the BFR in 480 to be a lot more comfortable to shoot than my SRH. (Would love to own a Freedom Arms SA in that caliber.) That is for the OP and looking at the 45-70 BFR..... Comfortable to shoot is where the X-frames come into play.
Comfortable to shoot.... I know most of us like our S&W M29's and M57's, but they really aren't comfortable to shoot with full power loads, ya know. But they are fun. Craig mentioned a 4" M29/629 as beating you up... I agree. Even the 4" is a big heavy on the belt for me.
There really are a lot of good tidbits in this thread for the budding big bore handgun hunter.