Colt's frames and cylinders are actually some of the strongest ever used in a DA revolver.
Colt used very high grade forged frames so they don't have to be as massive as Ruger's cast frames to have the same or better strength.
What wears, is the action, specifically the hand that rotates the cylinder. This can wear and cause the cylinder to not rotate quite far enough to lock fully.
When the trigger is pulled the cylinder will lock so it's safe to shoot.
The hand in the Colt's is considered to be a normal maintenance item IF it ever does wear to the point where it needs to be repaired.
This is like installing new spark plugs in an expensive car. For the higher performance, you have to do more maintenance.
In any revolver, shooting hot .357 Magnum will wear the gun more then shooting standard .38 Special ammo.
That's like driving a car at 100MPH or 70MPH.
In most revolvers it isn't the fame or cylinder that wear from hot ammo, unless it non-standard extra hot reloaded ammo that damages the frame.
Depending on how much you plan to shoot, I'd either just have fun and shoot standard .357 ammo, or just buy a couple of Brownell's bronze chamber brushes and clean the chambers regularly if you shoot .38 Special.
I've got a lot of rounds through a couple of stainless Pythons, about an even mix of light .38 Special reloads and a good amount of standard factory .357.
Both are in perfect condition.
One thing that "can" be rough on a .357 is shooting the hot 125 grain Magnum loads.
These can erode and even crack the forcing cone in the rear of the barrel. Shooting bullets in the 135 to 158 grain range are much easier on the gun.