Very roughly, the 6.5 Grendel shoots a narrower bullet of similar weight to what the 6.8SPC shoots. The narrower profile of the 6.5 Grendel bullet means the ballistic coefficient (BC), a measure of how easily it slips through the air, is higher. The 6.5 Grendel will lose velocity at a slower rate than the 6.8SPC, and consequently, the 6.5 Grendel will have less drop at the same distance vs. 6.8SPC. The difference is academic within 300 meters, but starts to add up at 500 meters and beyond.
As an analogy, you could think of 6.5 Grendel to 6.8SPC kind of like miniature versions of 7Mag vs. .30-06. With a 150gr bullet, both are right around 3000fps, but the 7Mag's bullet is slimmer and it retains velocity better and has less drop.
I think we're still waiting for good terminal ballistics data on te 6.5 Grendel, but some with experience in FBI-protocol gel tests believe the 6.5 will have a longer "neck" (before violent expansion/tumbling) in the wound profile.
-z