I have and use a 375 RUM and 376.
With the Styer stock the 376 is sure easy to shoulder. My like for this stock has led to multiple purchases.
For the specified region, a 338 wm with 225-250 bullets is the most practical choice.
IF-IF-IF any round would be classified as "practical" I'd easily chose the 376.
Those heartless ba$+ard$ at Hornady seem to have abandoned this round.
Then along comes the 375 ruger - hummm...........
But, I'd put a 24-26" tube on it and shoot some 300gr solids with some 270gr sp for the short stuff.
I don't think you could go wrong with any 35cal or bigger.
I honestly believe a smaller than 30cal would get you in over your head at some point.
I honestly think a blind magazine or hinged floorplate is a requirement in remote areas.
Having lost a mag once:banghead: - you get the point.
Any rifle would work - but a rifle with controls that would work with mittens or gloves is most desired IMHO.
An adjustable length of pull ( Steyr Prohunter ) to compensate for clothing layers would also be of great benefit.
The 8mm mag is an excellent round but it's dead.
Now the 7mm STW - that's another story.