I have never tried this. Manufacturer's blend powder stocks all the time to achieve a consistent pressure curve, but with one type of powder, and all lots are chemically consistent because they are made by the same manufacturer.
Blending different powders based on layer cake theories is risky. It assumes there will not be strange interactions between different powders. There may be.
I have seen solid rocket motors which were cast like layer cakes. There was a different burn rate between layers, but, the layers were hard, like cheese hard, and by the time the fire got to those layers, the old layers were gone. Gunpowders are granules that mix well, I don't see how you can keep the layers segregated during combustion. I don't believe that the faster powders will ignite first and then the slower powders. I think ignition is far more complicated than the candle stick model assumed by the Duplex loaders.
And, I have never seen a pressure curve. Don't know what the pressure curve looks like. If small changes result in extreme pressure curve spikes, that is duplex loading is basically unstable and unpredictable, I don't want any of it. The rifle case loads with Blue Dot are an example of this. Alliant does not recommend them because small changes in anything result in a pressure spike. Still there are shooters using Blue Dot in their 223 and other calibers and it does not take much search time to find examples of rifles that blew up with Blue Dot.
Science is advanced by dreamers who test their models and find what works. Bad ideas are dumped and people forget why. Duplex reloading must have been a failure, or we would all be doing it.