I carry the following,
Ruger LCR 38 special, de santis nemesis pocket carry in coats when I wear them, or ankle carry if I'm trying to be sneaky, loaded with federal micro hst 150gn.
Ruger LCP 380, smart band appendix carry in anything most of the time, or DeSantis nemesis if a quick trip, loaded with 380 gold dot, but I want winchester pdx if I ever find some.
Glock 26 9mm, galco king tuk iwb @ 3:30 position when I really want a gun but must conceal, loaded with 147gn winchester ranger T
Glock 17 9mm, galco silhouette high-ride owb or in a galco Miami shoulder rig, when I really want 2-legged protection, loaded with winchester ranger T 147gn
Glock 20 10mm, galco silhouette high-ride own, when I want to hike, loaded with 180gn FMJ hand loads at 1300fps
Ruger Super Redhawk 44 magnum, galco Kodiak chest rig for bear country with 300gn wfn hard cast hand loads at 1300fps.
Or a Ruger Super blawkhawk with some belt holster galco low draw own in 44 mag, same 300 gn wfn 1300fps loads.
I pick ammo based on hunting wisdom (4-legged protection) or gel testing (2-legged protection), the lucky gunner data is why I picked what I have currently along with shootingthebull ammoquest for 380.