if you're willing to drill it in it works, but I've spent too much time drilling in a smooth draw, present, swipe thumb down motion. It works for "right" safety levers, and it works for "no safety lever" guns.BFD, I look at the safety as being non-traditional and not "wrong",
I like it because it fits MY hand ... your hand might prefer the 22/45 grip if the rake on the traditional Ruger .22 pistol isn't your cup of tea.I have never liked the swept-back grip angle on the Mark pistols although they do look sweet.