For the price the Ruger P95 can't be beat. I've had one for 8 years now without a SINGLE malfunction. I own 3 other 9mm's (Walther, SIG, and S&W M&P) and if complete and utter reliability was the concern, I'd give the nod firmly to the Ruger.
The tradeoff that you do make is in ergonomics (it's not that comfortable in the hand), and to some degree accuracy (no problem admitting that it's not a tack driver, but it's passably accurate).
For right around $300 it's the best bet in a NEW handgun. If you're willing to shop used, than that's another matter. You can probably get guns that are better in some categories for the same price used, and they might bas AS reliable, but I don't think you'll find one that's MORE reliable.