H110 and W296 are great magnum powders but they lack versatility as they are density sensitive in that they need to be loaded to a level that will develop enough pressure for the powder to properly burn. Use to light a load, fail to use heavy crimp and magnum primer and it can and will produce squibs, which means that the powder doesn't burn and the bullet is usually pushed into the barrel by the primer. If another round is fired after a bore obstruction from the squib it will result in a ruptured, blown up or bulged barrel.
Its lack of flexibility will show if you find you are getting leading from your cast bullets at full magnum velocities since there's little to no allowance in charge reduction. Most manuals say do not reduce below 3% of maximum or do not go below minimum listed load.
As a relatively slow powder you also use a lot of it per load so its not an economical powder and the fire ball is greater than a faster powder. H110 will flame cut your revolver quicker as more hot gasses are produced.
Personally I think of H110 as a specialty powder for magnum loads in my .357 and .41 mags using jacketed bullets. I don't use it with 125gr bullets as there are better powders for that light a bullet but with 140gr and heavier it does work very well and produces accurate ammo.
I prefer Unique or W231 for moderate level loads using cast bullet, AA9 or 2400 for full magnum level with cast.
Below is Hodgdon's data for H110 in the .357 mag and note the narrow powder range. Also note they don't list any cast bullets in their data though you can find data in Lyman for use with their cast bullets though it probably best in bullets with gas checks.
