I am using recently-purchased "4227" that is labeled with the IMR label. It is made in Canada. I read and believe the same thing Wrong Handed posted about it being H4227 but now labeled as IMR4227. I suggest using current load data from Hodgdon's online reloading reference.
4227 is an interesting powder, well-worth experimenting with. It is a single-base powder, using only nitrocellulose (gun cotton) and no nitroglycerin. From the looks of it, it appears to be an extruded tube-shaped powder. The granules are like little hollow cylinders, but they're short so they almost look like mini donuts. Based on my experience, it is somewhat hard to ignite, especially with compressed loads. I have not yet, but would suggest trying it with magnum primers, particularly with those compressed loads in .357 magnum where the "book" calls for magnum primers.
4227 is a "magnum" powder in the sense that it can deliver full .357 magnum performance as seen with powders like 2400, H110, and Lil Gun. Similarly, it may not be advisable to use it for light or medium loads (haven't tried it). With published starting loads in .357 magnum, it gives decent velocity and I get the perception that it's softer-shooting than H110. It just seems tamer in the blast and report. As I increased the charge, it did not keep up with H110. Near max loads, the velocity was considerably less than similar loads with H110. Again, I suspect I wasn't getting good ignition.
It is notorious for blowing powder skeletons. With starting loads, I didn't see too much problem. Near max loads, it was really blowing debris all over which I could see because of the snow on the ground.
Theoretically, it should be easier on the gun than H110 or Lil Gun in terms of throat erosion because of a lower flame temperature and less powder scouring.
I never tried it and don't see much point to using it at .38 Special pressure levels. But I do like it in published starting .357 loads, and even there it is outperforming the faster burning powders.
Let's see, what else? It's not the most economical powder. It takes a case full. But it does offer a margin of safety against overcharging .357 (you can't fit too much powder). Overall, I might like it better than H110, but I'm introducing myself to Lil Gun which might turn out to be my favorite.