As you can see from the replies, the 45acp works great from several powders. Unique doesn't meter as well as some, but it is a near perfect powder for the heavier weight bullets. 231 works great for reduced and cast loads. Bullseye is a bit dirty and you may notice a bit more recoil with full loads, but it is economical. Other powders I have used include Green Dot and American select. I've been wanting to try WSF. It worked great in my 9mm, but I ran out before trying it in 45ACP. Longshot, Tightgroup and Power Pistol are also on the short list to try.
If you don't want to weigh every charge, 231, Bulleye and WSF meter better than the flake powders such as Unique, Green Dot etc.
Since I load mainly soft target ammo, I choose 231. Unique should serve you well for your intended purpose.