I have also done some work in this area, having designed and built two 9mm pistols with identical-length barrels (4.2" - same length as HKP7-series). The first gun has a gas-delay blowback system, with .0005" clearance between the two piston lands and the cylinder wall, and the second gun is a lock-breech design. After having fired multiple brands of ammunition, I have found an average of 5% more kinetic energy coming out of the locked-breech gun than the gas-delay gun. Slide travel is about .08" when the bullet leaves the barrel in both guns. When I compare the ballistics to the HKP7, the locked-breech gun delivers about 12% more kinetic energy than the P7. I believe that this due to the grooves that HK adds to the chamber to help "float" the case out of the chamber to improve reliability. This translates to 40-50 ft-lbs of loss using +P ammunition.
A locked-breech gun's chamber is no more "sealed" than any other type of gun mechanism. In fact, some locked-breech guns, such as the S&W sigma series and Kel-tec, have much larger chamber clearance than, say, a Kahr, resulting in an additional energy loss of about 4-7% over the tighter-chambered brands.