It just depends...... folks that are SASS shooters will load differently than plinkers, "max loaders", and NMLRA Line Shooters.
How accurate do you want to be and how far are you going to shoot? Are you shooting to win a match or just enjoying an afternoon off?
Define "accuracy"? Are you shooting at a CAS metal silhouette at 7 yards or a "B-6 (T)" target at 50 yards?
I've been shooting NMLRA Line Matches since 1987, so I can only recommend my loads to someone who either wants to shoot the best score he can at 25 yards & 50 yards, or win line matches at a NMLRA club shoot.
Like some here who have already advised, I use 20 grains of Swiss 3FG followed by cream of wheat that fills 7/8's of the cylinder in my Ruger Old Army & my Navy Arms Remington Deluxe Model .44 caliber (AKA Pietta "Shooters Model"), then a Hornady .457 RB, followed by grease. I use a cylinder press.
It just depends.......25 yards, one hand, NAC New Model Army Remington Deluxe Model,